MovDisordV3, Main, Exploration, bibRecord, 003488

Diffusion‐weighted imaging in Huntington's disease

Identifieur interne : 003488 ( Main/Exploration ); précédent : 003487; suivant : 003489

Diffusion‐weighted imaging in Huntington's disease

Auteurs : Klaus Seppi [Autriche] ; Michael F. H. Schocke [Autriche] ; Katherina J. Mair [Autriche] ; Regina Esterhammer [Autriche] ; Helga Weirich-Schwaiger [Autriche] ; Barbara Utermann [Autriche] ; Karl Egger [Autriche] ; Christian Brenneis [Autriche] ; Roberta Granata [Autriche] ; Sylvia Boesch [Autriche] ; Werner Poewe [Autriche] ; Gregor K. Wenning [Autriche]

Source :

Movement Disorders [ 0885-3185 ] ; 2006-07.

RBID : ISTEX:0477617B883DD12E56B179CF5CA67DACE7356266

Descripteurs français

Pascal (Inist)
- Chorée Huntington, Imagerie RMN, Imagerie de diffusion, Système nerveux pathologie.

English descriptors

KwdEn :
- Activities of Daily Living (classification), Adult, Aged, Basal Ganglia (pathology), Diffusion Magnetic Resonance Imaging, Diffusion imaging, Disease Progression, Female, Humans, Huntington Disease (diagnosis), Huntington disease, Huntington's disease, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Nervous system diseases, Nuclear magnetic resonance imaging, Reference Values, Severity of Illness Index, Thalamus (pathology), diffusion‐weighted imaging, magnetic resonance imaging, striatum.
MESH :
- classification : Activities of Daily Living.
- diagnosis : Huntington Disease.
- pathology : Basal Ganglia, Thalamus.
- Adult, Aged, Diffusion Magnetic Resonance Imaging, Disease Progression, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Severity of Illness Index.

Abstract

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder that results from an expanded trinucleotide (CAG) repeat on the huntingtin gene. Neurodegeneration in HD affects most prominently the basal ganglia. Therefore, diffusivity was obtained in the basal ganglia and thalamus of 29 patients with early HD and 27 healthy volunteers by means of the trace of the diffusion tensor (Trace(D)). Putaminal, caudate, pallidal, and thalamic Trace(D) values were increased in patients with HD compared with controls. Increased diffusivity in the putamen and caudate nucleus correlated with global functional impairment, CAG repeat length, as well as bicaudate ratio. Diffusion‐weighted imaging appears to be a promising surrogate marker for disease severity in HD. Sensitivity to change remains to be established longitudinally. © 2006 Movement Disorder Society

Url:

https://api.istex.fr/document/0477617B883DD12E56B179CF5CA67DACE7356266/fulltext/pdf

DOI: 10.1002/mds.20868

Affiliations:

Le document en format XML

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<term>Diffusion Magnetic Resonance Imaging</term>
<term>Diffusion imaging</term>
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<front><div type="abstract" xml:lang="en">Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder that results from an expanded trinucleotide (CAG) repeat on the huntingtin gene. Neurodegeneration in HD affects most prominently the basal ganglia. Therefore, diffusivity was obtained in the basal ganglia and thalamus of 29 patients with early HD and 27 healthy volunteers by means of the trace of the diffusion tensor (Trace(D)). Putaminal, caudate, pallidal, and thalamic Trace(D) values were increased in patients with HD compared with controls. Increased diffusivity in the putamen and caudate nucleus correlated with global functional impairment, CAG repeat length, as well as bicaudate ratio. Diffusion‐weighted imaging appears to be a promising surrogate marker for disease severity in HD. Sensitivity to change remains to be established longitudinally. © 2006 Movement Disorder Society</div>
</front>
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<name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name>
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Movement Disorders (revue)

Diffusion‐weighted imaging in Huntington's disease

Diffusion‐weighted imaging in Huntington's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.